iT6 ‘s M&A Consulting

Regenerative medical consulting

Regenerative Medicine is the process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal functions. In general, regenerative medicine is conducted by three different kinds of cells including embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and somatic stem cells. Our company’s domain area is somatic stem cells and these cells have functions of cell differentiation. Notably, it is generally considered that somatic stem cells which are isolated from a client’s body and cultivated in vitro are less likely to be rejected after returning to the client’s body.
Therefore, we are committed to dealing with somatic stem cells medicine consultation for clinics.

(※)Click the image to see a larger version

(※)Click the image to see a larger version 

In the case of opening a new clinic specialized in regenerative medicine, it is mandatory to receive permissions from the Certified Special Committee for Regenerative Medicine as well as from a health center, and then submit a provision plan to the Minister of Health, Labour and Welfare (MHLW). In order to establish a Cell Processing Center (CPC) within a clinic, it is also mandatory that a given clinic be investigated by Pharmaceuticals and Medical Devices Agency (PMDA). In addition, after CPC is in place, a regular report of its quality assurance to PMDA is mandatory. We offer a one-stop consultation solution in helping to open regenerative medicine clinics as follows:

  • We introduce appropriate experts such as regenerative medicine specialists.
  • We offer renovation consultation including the selection of a location, the expansion of an existing facility and other renovation matters.
  • We provide appropriate assistance for obtaining permissions as well as submitting legal documents.
  • We provide assistance for establishing medical facilities including CPC.
  • We provide necessary employment support and human resources education.
  • We provide management support after clinics are opened.

Genome Medical Consultation

With the help of the development of information technology (IT), genetic analysis technology has shown its rapid progress. In the past, analyzing human genome required at least 10 years and a 300 billion yen budge. Nowadays its analytical term is about 7 days and a 500,000 yen’s budget. Taking advantage of this technology paved the way for precision medicine. This medical model proposes to analyze cancer cell genetics and tailor products to respective types of cancers.

The main cause of cancer happens when abnormal cell growth invades or spreads through the body. Abnormal cell growth causes the occurrence of abnormal protein which leads to cancer cell growth. If gene mutation of cancer cells, which cause abnormal protein growth, can be identified, the suppression of abnormal protein growth is a real possibility. In other words, medicine effective in suppressing abnormal protein growth could be used to cure cancer. In cancer, depending on the type of treatments, drugs or other substances to target specific molecules are used, which are called ‘molecular targeted drugs.’ Although the progress of precision medicine technology has shown its partial improvement in rare cancer treatments, the number of medical institutions and analytical centers specializing in this area are still limited in Japan.

(※)Click the image to see a larger version

(※)Click the image to see a larger version

Nonetheless, regarding the analysis of the abnormal growth of cancer cells, we are promoting partnerships with medical institutions and laboratory centers not only in Japan, but also overseas. We are committed to moving beyond the normal practices of today, and furthering the advancement of the utilization of precision medicine in medical institutions.

Telemedicine Consultation

A good example of setting up an online clinic is as follows:
According to the data regarding 2016’s National Health and Nutrition Survey by Ministry of Health, Labor and Welfare (MHLW), the current number of diabetic patients were about 10 million in addition to about 10 million people who may suffer from diabetes in the future. Those patients are required to receive regular face-to-face medical treatment and prescription. They usually spend longer hours waiting in an office until they receive a medical treatment. These long hours of waiting lead to patients’ giving up their treatment and more severe diabetic conditions. As a result, this has caused the major increase in medical costs. This not only applies to diabetic patients, but to other patients also. In order to address this, telemedicine/an online clinic is suggested as one of medical solutions by the national policies.
Online medical treatment is limited to the following diseases:

(※)Click the image to see a larger version

To conduct online treatments, personal computers and smart phones as well as smart tablets are generally used. Advanced medical appointment reduces waiting time. If prescription is provided directly by a medical institution, it also enables a given medical institution to send a medicine by post. Therefore, patients do not have to go to a drugstore to purchase their medicine.
Our consultation ranges from the introduction of online treatment to its management.

(※)Click the image to see a larger version

(※)Click the image to see a larger version

As far as online treatment goes, it is essential to collect a patient’s vital data. In particular, since people with chronic disease patients’ symptoms are gradually getting worse, it is necessary to collect data such as blood glucose levels, blood pressure, heart rate and others to have better treatment.
We also offer consultation for helping to build a medical system by utilizing patients’ data collected from their wearable device in addition to artificial intelligence (AI), which enable us to discover potential for new diseases. For further information, please refer to the Medical Data Utilizing Consultation.

The Medical Data Utilizing Consultation

The system and data involving medical institutions are follows:

  1. Electronic medical record system
  2. Ordering system
  3. Medical image system
  4. Medical accounting system
  5. Radiation information system
  6. Clinical examination system
  7. Physiological examination system
  8. Surgery information system
  9. Nutrition management system
  10. Article management system
  11. Medical information management system
  12. Regional medical cooperation system
  13. Rehabilitation support system
  14. Medical checkup system
  15. Automatic reservation system
  16. Regenerative medical treatment system
  17. Customer management/sales management system
  18. Genome data
  19. AI system
  20. Patients’ vital data
  21. Dispensing system

Among various medical systems, the penetration rate of an electronic medical data system is currently only 38.9%, which is a typical type of a medical system. This rate suggests that by utilizing the above systems and available data, we believe medical rationalization, efficiency and optimization will be promoted from the various points of view. This also will benefit medical institutions, patients as well as the government.

(※)Click the image to see a larger version

For example, the following are possible:

  • Optimization and efficiency of making appointments and waiting time
  • Earlier discovery of disease
  • Optimal route/costs to treatment completion
  • Earlier discovery of new disease
  • Disease prevention/Promotion of preventive medical treatment
  • Medical discovery of innovative knowledge

We are committed to doing the following things:

  • Prioritizing each medical institution’ issues.
  • Supporting building a management system and selecting appropriate products and vendors in accordance with each client’s original resources.
  • Supporting data analysis consultation.
  • Providing consultation for medical data utilization including management outsourcing.

In the mid-term and the long term, we will strive for contribution to medical development and efficiency by combining common data from each independent medical institution.

Medical regeneration consulting

1.Department with Negative Earnings

When a hospital has several departments, it tends to have departments with negative earnings, even though the hospital itself has a
positive figure.
We seek the cause of the negative earnings and work out specific effective measures.
Negative earnings can be divided into following patterns.

Pattern 1.Structual cause such as limited number of target patients in the area

In this pattern, we recommend to close the department on some occasions. However, it will create new issues including the care for the
physicians and nurses, and disposition of undepreciated facilities. In addition, the institution needs to make a plan for expansion or
establishment of the potential positive earning department.

Unbalanced management such as excessive facility investment without prospects of capital recovery.

When the institution can expect a certain number of patients, its earnings can be changed to positive figures by conducting an appropreate
management plan.
When the cause is clarified, hospital management can go from red to black by solving the problem. As such success cannot be achieved in a short term, iT6 supports you step by step. We have been supporting various medical institutions to close, expand and establish departments
by introduction of physicians, arrangement of medical divices and appliciation support to the authorities, based on our unique medical
information database. Closure and establishment of department are the long-term issues to be considered.
iT6 supports the long-term planning of medical institutions, including the specific department rearrangement plan and equipment renewal
in each department.

2.Institutions with Successor Problem

During the rapid economic growth period, a large number of medical institutions opened in various regions, along with the expansion of city area. Now, medical institution management has reached its turning point, due to the changes in social environment such as low birth rate. Many institutions are closing down, and its procedure is complicated. Even the succession procedure to the next generation is more complicated than the procedure of startup. Furthermore, there are separate paperwork between the medical institution and pharmaceutical companies or medical device companies.
iT6 has been carefully solving these legal and management problems by untangling the specific issues of each institution. In some occasions, healthcare M&A technique needs to be used.
Closing down a town hospital can lead to a medical system collapse in the area. Healthy town consists of health maintenance of every person in the community. iT6 supports medical institution management in regional areas to help maintaining the health of reginal society in Japan.

3.iT6’s Risk Management

As medical practice is conducted by human, small or large risks are unavoidable. Physicians and nurses are not 100% perfect because they are human. iT6’s risk management support takes immediate action to the accidents occurred in hospitals and clinics.
Care for the patients, and care for their family.
iT6 faces each accident with hospitality in mind, and do our best to support the patients and their family, and the medical institutions.

Medical regeneration consulting

1.Department with Negative Earnings

When a hospital has several departments, it tends to have departments with negative earnings, even though the hospital itself has a
positive figure.
We seek the cause of the negative earnings and work out specific effective measures.
Negative earnings can be divided into following patterns.

Pattern 1.Structual cause such as limited number of target patients in the area

In this pattern, we recommend to close the department on some occasions. However, it will create new issues including the care for the
physicians and nurses, and disposition of undepreciated facilities. In addition, the institution needs to make a plan for expansion or
establishment of the potential positive earning department.

Unbalanced management such as excessive facility investment without prospects of capital recovery.

When the institution can expect a certain number of patients, its earnings can be changed to positive figures by conducting an appropreate
management plan.
When the cause is clarified, hospital management can go from red to black by solving the problem. As such success cannot be achieved in a short term, iT6 supports you step by step. We have been supporting various medical institutions to close, expand and establish departments
by introduction of physicians, arrangement of medical divices and appliciation support to the authorities, based on our unique medical
information database. Closure and establishment of department are the long-term issues to be considered.
iT6 supports the long-term planning of medical institutions, including the specific department rearrangement plan and equipment renewal
in each department.

2.Institutions with Successor Problem

During the rapid economic growth period, a large number of medical institutions opened in various regions, along with the expansion of city area. Now, medical institution management has reached its turning point, due to the changes in social environment such as low birth rate. Many institutions are closing down, and its procedure is complicated. Even the succession procedure to the next generation is more complicated than the procedure of startup. Furthermore, there are separate paperwork between the medical institution and pharmaceutical companies or medical device companies.
iT6 has been carefully solving these legal and management problems by untangling the specific issues of each institution. In some occasions, healthcare M&A technique needs to be used.
Closing down a town hospital can lead to a medical system collapse in the area. Healthy town consists of health maintenance of every person in the community. iT6 supports medical institution management in regional areas to help maintaining the health of reginal society in Japan.

3.iT6’s Risk Management

As medical practice is conducted by human, small or large risks are unavoidable. Physicians and nurses are not 100% perfect because they are human. iT6’s risk management support takes immediate action to the accidents occurred in hospitals and clinics.
Care for the patients, and care for their family.
iT6 faces each accident with hospitality in mind, and do our best to support the patients and their family, and the medical institutions.

Investment

– Private Equity (PE)
– Corporation Venture Capital (CVC)

We proactively invest in our domain organizations including medical institutions, general companies, venture companies, and others dealing in the following areas:

  • Regenerative Medicine
  • Genome Medicine
  • Telemedicine Examination
  • Medicine/Healthcare Data
  • Elimination And Efficiency of Medical Information Asymmetry

In these fields, business circumstances are always changing their faces from the perspective of both external and internal environments. In addition, this trend of evolution never stops so that we cannot anticipate stable markets in these areas. Against the backdrop of these situations, going one step further, we certainly need to create a de facto standard model or a solid platform which will generate business chances. These should be shared with users, consumers, patients, the government, related business organizations, and others. Considering the current trends, we should always keep the pace with the markets and stay on top of issues.

Under these circumstances, we should work closely together rather than working solely. Combined sources through partnership will help us achieve our business vision. We are willing to invest in medical institutions, related companies, and venture business companies.

The following are our investment policies.
The investing stage: Our investments including corporate venture capital (CVC) and corporate venture investment are basically the seed or the early investing stages.

(※)Click the image to see a larger version

Investment Approaches/Investment Policies

Private Equity (PE)

This transaction requires 100% acquisition of shares or at least more than 50% acquisition of shares. However, we are always in a position to accept other financial considerations.

Corporate Venture Capital (CVC)

Our policy, in terms of whether we will invest or not, will be determined based on the next investment acceptance plan or capital polity, and a planned exit of repayment. Since our principal investment periods for CVC are from a seed stage to an early stage, we also support our clients’ formulating their capital planning.

The same policy is applied for PE and CVC

We accept mezzanine financing as well as the transfers of shares and a third party allotment increase.

The principle

In principle, we do not make investments for the financial gain purposes such as income fund investment, capital gain investment, and others. We only make investments which promote our businesses and stimulate synergy.

CONTACT US

Those with investment information and interested in working with us, please feel free to contact us.
* Those with investment information are subject to be connected with their sell-sides.